From Gozo to Warsaw: 7 Ketamine Clinics in Europe to Restart Mental Well-being
Ketamine therapy is gaining more and more recognition as an effective option for treatment-resistant depression, PTSD, and anxiety disorders. We’ve selected seven top clinics across Europe, ranging from affordable to luxury, that offer ketamine-assisted psychotherapy and comprehensive integrative care.
Hive Bio
Malta
Set inside a restored villa near Żebbuġ’s dramatic limestone cliffs and the famed Inland Sea on Gozo — Malta’s quieter sister island — HIVE BIO Malta offers a rare experience in the psychedelic therapy landscape: a ketamine-assisted psychotherapy program with the rhythm of a retreat. Here, boutique hospitality meets clinical precision, so after a guided ketamine session, you might find yourself in silent meditation at sunset, surrounded by nature, and knowing you’re under the care of a licensed medical team. But HIVE BIO is not just about the setting.
Most clinics offer outpatient ketamine, where patients return home — often straight back into the same stress loops or emotional triggers that contributed to their suffering in the first place. But research shows that after a ketamine session, there is a 72-hour window of heightened neuroplasticity. The brain becomes more flexible, receptive, and open to change. At HIVE BIO, this window isn’t wasted, it’s fully activated.
HIVE BIO’s flagship “3-1-3” program (three weeks of online preparation, one intensive week on-site in Gozo, and three weeks of guided integration online after returning home) includes up toup to three or four ketamine sessions, overseen by a multidisciplinary team of psychiatrists, psychotherapists, and medical professionals.
Each day includes carefully curated support practices: breathwork, sound healing, art therapy, yoga, Mediterranean meals, ice baths, and sunset meditations in an olive grove. There’s also space for play, rest, and embodied creativity — from hand-lettering workshops to floating in the pool. Most importantly, therapy doesn’t stop with the session.
Co-founded by neuroscientist Dr. Nataliya Vorobyeva and lawyer, founder, and entrepreneur Alex Latyshev, HIVE BIO positions itself at the intersection of next-gen mental health care and regulated access to psychedelic therapies.
“At HIVE BIO, ketamine is not a magic pill — it’s a catalyst. We combine it with individual and group therapy, body-based practices, and structured tools that help people reconnect with themselves and build sustainable change. Depression is often a symptom, not a cause — and we aim to go deeper, — explains Nataliya Vorobyeva in conversation with States Of Mind. — Our clients come with more than diagnoses, they come with stories: TRD, MDD, anxiety, burnout, emotional shutdown, behavioral addiction, post-COVID fatigue, and more”.
And at HIVE BIO, they don’t aim for the happy ending of each story, they aim for a happy journey.
Ketaminplus
Ketaminplus, with clinics in Palma de Mallorca, Andalusia, Berlin, and Munich, offers an integrative approach to mental health and psychosomatic care under the direction of Dr. Mario Scheib — a long-time specialist in psychosomatic medicine.
Since 2015, Dr. Scheib has combined ketamine-assisted therapy with personalized psychotherapy and advanced techniques such as rTMS (repetitive transcranial magnetic stimulation), neurofeedback, and virtual reality. The clinic focuses on treating depression, PTSD, anxiety disorders, addiction, OCD, and burnout, particularly in patients who haven’t responded to traditional treatments like antidepressants or even electroconvulsive therapy.
Many patients report rapid progress: one described three weeks of intensive therapy in Mallorca as more effective than years of conventional treatment. This two- to three-week model is standard at the Palma clinic, which offers residential programs in a private facility for patients traveling from abroad.
The Andalusia location, by contrast, provides outpatient care tailored to residents and short-stay visitors. Both clinics emphasize highly personalized plans, often including sleep diagnostics, HRV analysis, hypnosis, and biofeedback, guided by the clinic’s philosophy of “orienting therapy to the person, not the other way around.”
Beyond clinical care, Ketaminplus also serves as a training center. In October 2025, the team will host an international conference in Frankfurt for doctors and psychotherapists, exploring the combined use of ketamine, psychotherapy, and neuromodulation.
Clinica Synaptica
Just a few minutes from the Arc de Triomf and the Banksy Museum, Clínica Synaptica sits on the edge of Barcelona’s old city — somewhere between a wellness space and a clinical office. From the outside, it might look like any other urban clinic, but inside, the approach is deliberately progressive. While Synaptica operates firmly within a clinical model, its treatment protocols reflect a broader interest in embodied healing and non-ordinary states.
The clinic was founded by Dr. Joan Obiols, a psychiatrist whose background spans both hospital psychiatry and harm-reduction work in festival settings. Here ketamine is used not as a standalone solution but folded into broader therapeutic frameworks such as somatic practices, psychotherapy, and biofeedback, under the guidance of a licensed psychiatric team.
Most patients arrive with long-standing conditions: treatment-resistant depression, anxiety, PTSD, or psychosomatic pain. The process starts with a thorough intake, followed by ketamine sessions tailored to the individual and often accompanied by somatic techniques like TRE (Tension & Trauma Releasing Exercises), group therapy, or guided bodywork.
Synaptica isn’t a wellness retreat, but it tends toward something more holistic than conventional psychiatry. It’s also part of a growing research ecosystem where patients can opt into studies exploring ketamine’s effects on trauma and chronic inflammation.
Ovid Clinic
Germany
Since opening in 2021, OVID has positioned itself at the intersection of academic psychiatry and integrative care, with a particular focus on ketamine-assisted psychotherapy (KAP) and, more recently, psilocybin under Germany’s compassionate use framework.
The clinic is founded by psychiatrist and researcher Prof. Dr. Gerhard Gründer, a key figure in Germany’s psilocybin research landscape, and Dr. Andrea Jungaberle, a physician and co-investigator in the country’s first major psilocybin depression study. Their clinical model draws directly from their work in academic settings like the Central Institute of Mental Health in Mannheim and Charité Berlin — institutions better known for randomized controlled trials than for day-to-day therapy.
In contrast to ketamine infusion clinics that operate closer to procedural medicine, OVID places pharmacological interventions within a framework of sustained psychotherapeutic engagement, often spanning four to twelve weeks in its day-treatment program. A typical treatment day might include individual therapy, mindfulness practice, music-based relaxation, and journaling, alongside creative tools like virtual reality or art therapy.
Like many psychedelic therapy centers, OVID aims to be a space for psychological transformation, but without departing from its psychiatric foundation, treating patients with complex diagnoses such as PTSD, chronic depression, and adjustment disorders linked to serious illness or loss. Its approach is neither purely biomedical nor fully holistic, instead emerging from a slow recalibration of psychiatry.
Oberberg Clinics
Germany
Founded in the late 1980s by neurologist Prof. Dr. Matthias Gottschaldt, the Oberberg network has grown into one of Germany’s most established providers of private mental health care. What began as a personal response to burnout and addiction has become a system of over 30 clinics, offering integrated psychiatric, psychotherapeutic, and psychosomatic treatment. Many are located in natural surroundings by forests or lakes, and are designed to feel calm and spacious, supporting long-term recovery.
While Oberberg doesn’t brand itself as a “psychedelic clinic,” it takes an integrative, evidence-based approach to mental health, combining advanced medical treatments with personalized and innovative biological therapies such as ketamine infusions and intranasal esketamine. Awake therapy, light therapy, and neurostimulation techniques add to the picture, setting clinics at the forefront of next-generation healing approach.
Another area where the Oberberg departs from typical biomedical models is their attention to food, integrating nutritional psychiatry into its therapeutic programming. The food here is not just sustenance, it’s considered part of the treatment ecology. Kitchens emphasize plant-forward, regional meals with accommodations for allergies, diabetes, and personal dietary choices, and eating together is framed as a relational act, where meals are designed to support mood, energy stability, and neurochemical balance.
With recovery practices like mindfulness, embodiment work, expressive arts, bibliotherapy and animal-assisted interventions, and luxury countryside settings, Oberberg might look like a wellness center. However, patients who arrive for multi-week stays, follow carefully designed protocols rooted in psychiatric guidelines. Some clinics also offer aftercare programs and “City Centers” to support post-discharge reintegration.
Research remains a central pillar: staff members publish in academic journals, and clinics regularly host CME-certified workshops and symposia on topics ranging from schema therapy to neurostimulation. The affiliated Oberberg Foundation also supports mental health research with annual grants, most recently offering €50,000 in funding for addiction-focused studies.
Psyon
Czech Republic
Founded by researchers and clinicians involved in the Czech Republic’s psychedelic renaissance, Psyon is among the first European clinics to offer ketamine-assisted psychotherapy within a comprehensive psychiatric framework. It operates at the intersection of mainstream and emerging treatments, where low-dose ketamine becomes a tool not just for symptom relief but for insight, transformation, and expanded consciousness.
The clinical team emphasizes ketamine’s unique capacity to soften rigid mental patterns, making unconscious material more accessible for therapeutic processing. This approach has drawn individuals facing treatment-resistant depression, PTSD, OCD, and eating disorders, for whom traditional psychiatric interventions have often fallen short. The goal is not merely symptom suppression but meaningful, sustainable change — a new relationship to one’s thoughts, past, and sense of self.
What sets Psyon apart is not only its clinical protocols but a cultural positioning. The clinic’s founders and therapists have trained with institutions like CIIS, MAPS, and Polaris Insight Center, and are connected to a global movement reviving psychedelic therapy with scientific precision and ethical care. The team also provides standard outpatient psychiatric services — a rare dual offering that allows for continuity of care across the psychedelic and conventional spectrum, as well as inclusion in public insurance systems.
The full course of ketamine-assisted therapy, spanning preparation, dosing, and integration, typically involves five or more sessions and lasts between 8 to 14 hours in total. While not all services are covered by insurance, Psyon collaborates with major Czech health insurers and offers partial reimbursement for qualifying clients — an unusual arrangement in the European context. A subsidy program is also available to make treatment more accessible.
KeyClinic
In Poland’s shifting mental health landscape, KeyClinic is a hybrid operation that blends clinical practice, public advocacy, and scientific research. From standard psychiatric consults to cutting-edge ketamine infusions, this Warsaw-based center is rethinking mental healthcare for all ages — from children and teens to adults.
Psychiatrists, psychotherapists, and neurologists here can help with anxiety, ADHD, OCD, bipolar disorder, and schizophrenia through talk therapy, medication management, TMS (transcranial magnetic stimulation), virtual reality–based trauma therapy, and psychedelic integration support.
But KeyClinic isn’t just treating people, it’s trying to change the ecosystem itself through its nonprofit foundation — taking on what it calls the “social determinants of mental illness.” That means subsidizing care for those who can’t afford it, supporting anti-stigma campaigns, contributing to global research on personalized treatments for depression and running education programs — both academic and infotainment, such as YouTube series Śniadania u Piotra (“Breakfasts at Piotr’s”) hosted by one of the clinic’s founders.
