Esketamine (Spravato)
Approved + off-label ketamineEsketamine is approved and used alongside off-label ketamine in clinics.
Australia
Last updated 18 August 2026
Psychedelic Therapy Legal Landscape
Ketamine Therapy
Legal (clinics)Off-label medical use plus esketamine.
Psilocybin
Legal medical pathway — world firstSince 1 July 2023, TGA-authorised psychiatrists can prescribe psilocybin for treatment-resistant depression (Schedule 8 for this use). Honest picture three years in: it works but remains expensive — often tens of thousands of dollars per course — with limited authorised psychiatrists. Legal does not yet mean accessible.
MDMA
Legal medical pathway — world firstSame decision: MDMA prescribable by TGA-authorised psychiatrists for PTSD since 1 July 2023 — the only standing national MDMA pathway in the world.
Medical Cannabis
Legal (Rx)Via TGA Special Access / Authorised Prescriber pathways since 2016.
Clinical Trials
Open routeActive trials alongside the authorised-prescriber pathway — university centers in Melbourne and Sydney. Participation is free; screening is strict; never pay for “trial access”.
Frequently asked questions — Australia
Is ketamine therapy legal in Australia?
Legal (clinics). Off-label medical use plus esketamine.
Is psilocybin legal in Australia?
Legal medical pathway — world first. Since 1 July 2023, TGA-authorised psychiatrists can prescribe psilocybin for treatment-resistant depression (Schedule 8 for this use).
Is MDMA therapy legal in Australia?
Legal medical pathway — world first. Same decision: MDMA prescribable by TGA-authorised psychiatrists for PTSD since 1 July 2023 — the only standing national MDMA pathway in the world.
Can I join a psychedelic clinical trial in Australia?
Active trials alongside the authorised-prescriber pathway — university centers in Melbourne and Sydney. Participation is free; screening is strict; never pay for "trial access".
