Psychedelics

Summary & key facts

This is a patent application that describes new chemical forms of harmine — a natural compound found in ayahuasca — that are designed to dissolve much better in water or in the mouth. The inventors say they make salts of harmine using simple acids (called uronic acids) or a mix of a carboxylic acid plus a simple sugar. Those new forms are meant to let harmine be made into easy-to-take products, and the patent also describes kits that pair the harmine formulation with DMT for combined use. This is a patent claim, not a clinical test, so it shows a way to make harmine easier to formulate but does not prove it is safe or effective as a medicine.

Key facts:

• Harmine is a chemical that naturally occurs in ayahuasca and is normally hard to dissolve well in water.
• The patent describes making salts of harmine with uronic acids, or with a carboxylic acid plus a monosaccharide (a simple sugar), to boost how well harmine dissolves.
• Improving solubility is useful if you want to make oral medicines, mouth-dissolving films, or other easy-to-take products because the active ingredient needs to dissolve to work in a formulation.
• The documents include the idea of a kit that contains the improved harmine formulation together with DMT (or a salt of DMT) and a carrier, so both could be supplied for combined administration.
• This is a patent filing published in 2024 by a company called Reconnect Labs. A patent filing describes an invention and claims rights, but it is not evidence that the product has been tested in people for safety or benefit.

Topics

Chemical synthesis and alkaloids Nicotinic Acetylcholine Receptors Study Psychedelics and Drug Studies

Categories

Clinical Psychology Psychology Social Sciences

Tags

Chemistry

Substances

Ayahuasca