Plant brew (DMT + MAOI)
One small trial, lots of retreat claims. A traditional Amazonian brew that combines DMT with plant compounds (MAO inhibitors) that make it orally active.
Not an approved treatment for any condition yet.
One card per condition, strongest evidence first. Hover or tap a label to see what it means; the numbers link to sources at the bottom of the page.
One small randomised trial. Nothing larger since.
In a 29-person placebo-controlled trial in Brazil, one ayahuasca session reduced depression scores within a week more than placebo.1
Compare every substance for treatment-resistant depression →
Ayahuasca for Mental Health and Personal GrowthAyahuasca’s effects, benefits and risks, from depression and anxiety to personal growth.Read the article 
DMT Study Offers Hope In Fight Against DepressionIn a Phase 2 trial, one DMT session led to 29% remission at two weeks, versus 12% on placebo.Read the article 
How to Choose a Psychedelic Therapy ProviderWhat credentials, safety checks and red flags to look for before you book.Read the article Research databaseNew studies, summarisedHundreds of papers on psychedelics and mental health, each with a plain-language summary and key facts.Browse the database Numbered in the order they appear above. We only use peer-reviewed papers, official company announcements (for trial status and topline results), regulators and trial registries.
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