Alcohol use disorder
Early researchSelf-report survey only.
In the same survey, 76% of respondents with past alcohol problems reported improvement. Self-selected and retrospective.1
Classic psychedelic
Mescaline: what the evidence shows
Almost no clinical research. What exists is self-report. The psychedelic in peyote and San Pedro cacti. There are no published controlled trials for any mental-health condition.
Not an approved treatment for any condition yet.
Condition by condition
One card per condition, strongest evidence first. Hover or tap a label to see what it means; the numbers link to sources at the bottom of the page.
Major depressive disorder (MDD)
Early researchSelf-report survey only.
In an online survey of 452 people who had used mescaline, most of those with a past depression diagnosis said it improved afterwards. Surveys like this can't show cause and effect.1
Compare every substance for major depressive disorder (MDD) →
Keep reading
Ayahuasca for Mental Health and Personal GrowthAyahuasca’s effects, benefits and risks, from depression and anxiety to personal growth.Read the article 
Before You Call Iboga a PsychedelicWestern medicine is turning iboga into ibogaine. In Gabon, the practice means something else.Read the article 
Do Difficult Psychedelic Experiences Hurt or Heal You? Inside The World’s Bad Trip DebateMost people say a hard trip helped them in the end, but not everyone. Inside the debate over challenging experiences.Read the article Research databaseNew studies, summarisedHundreds of papers on psychedelics and mental health, each with a plain-language summary and key facts.Browse the database Sources
Numbered in the order they appear above. We only use peer-reviewed papers, official company announcements (for trial status and topline results), regulators and trial registries.
